Diabetic Ketoacidosis (DKA) Explained Clearly Remastered – DKA Pathophysiology


Get clarity on DKA (diabetic ketoacidosis) with memorable illustrations from Dr. Seheult. See the DKA series free at This video is part of the “MedCram Remastered” series: A video we’ve re-edited & sped up to make learning even more efficient.

This is video 1 of 2 on diabetic ketoacidosis (pathophysiology and signs of diabetic ketoacidosis / DKA):

0:08 DKA stats
0:47 DKA – cellular anatomy
1:00 mitochondria
1:48 beta-oxidation
2:30 insulin function
3:08 pyruvate
3:19 diabetes mellitus type 1
3:26 diabetes mellitus type 2
4:48 ketone bodies (acetone, acetoacetate, b-hydroxybutyrate)
6:09 carboxylic acid
6:23 conjugate base (anion gap acidosis)
7:38 beta-oxidation
8:17 DKA review
8:57 diabetic ketoacidosis – hyperkalemia
9:37 diabetic ketoacidosis – dehydration
9:50 osmotic diuresis
10:10 dehydration
10:27 diabetic ketoacidosis – potassium effects
11:04 diabetic ketoacidosis – Cr elevation / renal failure
11:30 anion gap metabolic acidosis
12:09 measuring ketone bodies (serum ketones, b-hydroxybutyrate)

Visit for part 2 of this course (on DKA treatment) and over 100 lectures. This is the home for ALL MedCram.com medical videos (many medical videos, medical lectures, and quizzes are not on YouTube).

Speaker: Roger Seheult, MD
Co-Founder of MedCram.com (
Clinical and Exam Preparation Instructor
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.

Visit for hundreds of clear & concise videos

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Produced by Kyle Allred PA-C

Please note: MedCram medical videos, medical lectures, medical illustrations, and medical animations are for medical education and exam preparation purposes, and not intended to replace recommendations by your doctor or health care provider.