Ivermectin, is a Food and Drug Administration (FDA)-approved antiparasitic drug,
Direct from official FDA site
used to treat several neglected tropical diseases,
including onchocerciasis, helminthiases, and scabies.
For these indications, ivermectin has been widely used and is generally well-tolerated
Ivermectin is not approved by the FDA for the treatment of any viral infection.
Proposed Mechanism of Action and Rationale for Use in Patients With COVID-19
(in vitro studies)
suggest that ivermectin acts by,
Inhibiting host importin nuclear transport proteins
Interfere with SARS-CoV-2 spike protein attachment to the human cell membrane
Some studies of ivermectin have also reported potential anti-inflammatory properties
Shown to inhibit replication of SARS-CoV-2 in cell cultures
COVID-19 medical misinformation policy
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Treatment misinformation:
Content that claims that there’s a guaranteed cure for COVID-19
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Categorical claims that Ivermectin is an effective treatment for COVID-19
Claims that Ivermectin and Hydroxychloroquine are safe to use in the prevention of COVID-19
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Prevention misinformation: Content that promotes prevention methods that contradict local health authorities or the WHO.
Claims that there is a guaranteed prevention method for COVID-19
Claims that any medication or vaccination is a guaranteed prevention method for COVID-19
Content that recommends use of Ivermectin or Hydroxychloroquine for the prevention of COVID-19
Claims that Ivermectin and Hydroxychloroquine are safe to use in the prevention of COVID-19
Monitoring, Adverse Effects, and Drug-Drug Interactions
The FDA first issued a warning in April 2020 that ivermectin intended for use in animals should not be used to treat COVID-19 in humans. This warning was updated and reiterated in 2021.
FDA, Recommendation
The Panel recommends against the use of ivermectin for the treatment of COVID-19, except in clinical trials
The Panel will continue to review emerging data on ivermectin use, including the results from 2 large, ongoing randomized controlled trials.
Clinical Trials
Several clinical trials evaluating the use of ivermectin for the treatment of COVID-19 are currently underway or in development.
Please see ClinicalTrials.gov for the latest information.
Bangkok
Egypt
Malaysia
Is this one of the two?
Ivermectin to be investigated in adults aged 18+ as a possible treatment for COVID-19 in the PRINCIPLE trial
23 June 2021
Time line
