Orlis is indicated for obesity management including weight loss and weight maintenance when used in conjunction with a reduced-calorie diet.
ORLIS is also indicated to reduce the risk for weight regain after prior weight loss.
ORLIS is indicated for obese patients with an initial body mass index (BMI)≥30 kg/m2 or ≥27 kg/m in the presence of other risk factors (e.g., hypertension, diabetes, dyslipidemia).
Treatment with ORLIS should be discontinued after 12 weeks if patients have been unable to lose at least 5% of the body weight as measured at the start of therapy.
Dosage & Administration
The recommended dose of ORLIS is one 120-mg capsule three times a day with each main meal containing fat (during or up to 1 hour after the meal).
Based on fecal fat measurements, the effect of ORLIS is seen as soon as24-48 hours after dosing. Upon discontinuation of therapy, fecal fat content usually returns to pretreatment levels, within 48-72 hours
Doses above 120 mg three times a day have not been shown to provide additional benefit.
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